{"id":214707,"date":"2021-02-18T10:42:08","date_gmt":"2021-02-18T09:42:08","guid":{"rendered":"http:\/\/teacherilca.com\/?p=214707"},"modified":"2022-04-11T08:48:17","modified_gmt":"2022-04-11T07:48:17","slug":"scientifiques-chinois-developpent-therapie-genique-pourrait-retarder-vieillissement","status":"publish","type":"post","link":"https:\/\/teacherilca.com\/ja\/french-daily-news\/healthlifestyle\/scientifiques-chinois-developpent-therapie-genique-pourrait-retarder-vieillissement\/","title":{"rendered":"Une th\u00e9rapie g\u00e9nique qui pourrait retarder le vieillissement"},"content":{"rendered":"
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  1. \u30d5\u30e9\u30f3\u30b9\u8a9e\u306e\u8a18\u4e8b<\/a><\/li><\/ol><\/div><\/div><\/div><\/section>\n\n\n\n

    Une th\u00e9rapie g\u00e9nique qui pourrait retarder le vieillissement<\/h1><\/div><\/div>\n\n\n\n

    Th\u00e9rapie g\u00e9nique<\/strong> \u2013 science . La th\u00e9rapie g\u00e9nique est une technique exp\u00e9rimentale qui utilise des g\u00e8nes pour traiter ou pr\u00e9venir la maladie.<\/em>
    La poign\u00e9e \/ la prise<\/strong> \u2013  l\u2019acte de saisir ou de tenir quelque chose<\/em>
    Un Mammif\u00e8re<\/strong> \u2013 masculin. un type d\u2019animal qui donne du lait \u00e0 ses petits et qui a g\u00e9n\u00e9ralement des poils ou une fourrure recouvrant la majeure partie de sa peau<\/em>
    La toxicit\u00e9<\/strong> \u2013 medical masculin. la qualit\u00e9, l\u2019\u00e9tat ou le degr\u00e9 relatif d\u2019\u00eatre toxique ou toxique<\/em>
    Un Primate<\/strong> \u2013 masculin. tout membre du groupe d\u2019animaux qui comprend les \u00eatres humains, les singes et les singes<\/em><\/p><\/div><\/div>\n\n\n\n

    \u30d5\u30e9\u30f3\u30b9\u8a9e\u306e\u8a18\u4e8b<\/h2><\/div><\/div>\n\n\n\n

    Des scientifiques de P\u00e9kin, en Chine, ont mis au point une nouvelle th\u00e9rapie g\u00e9nique qui peut inverser certains des effets du vieillissement chez la souris. La th\u00e9rapie a \u00e9galement prolong\u00e9 leur vie. Cela pourrait aussi un jour aider les humains. La th\u00e9rapie g\u00e9nique impliquait la d\u00e9sactivation d\u2019un g\u00e8ne appel\u00e9 kat7. Les scientifiques ont d\u00e9couvert que ce g\u00e8ne \u00e9tait la principale cause du vieillissement des cellules.

    Qu Jing de l\u2019Institut de zoologie de l\u2019Acad\u00e9mie chinoise des sciences, ou CAS, est l\u2019un des superviseurs du projet. Apr\u00e8s six \u00e0 huit mois, a d\u00e9clar\u00e9 Qu, les souris ont montr\u00e9 une am\u00e9lioration globale de leur apparence et de leur force de pr\u00e9hension. Plus important encore, a-t-elle ajout\u00e9, \u00abils ont (une) dur\u00e9e de vie prolong\u00e9e (d\u2019environ 25%)\u00bb. Une autre \u00e9quipe de scientifiques de l\u2019acad\u00e9mie a utilis\u00e9 une m\u00e9thode appel\u00e9e CRISPR \/ Cas9 pour rechercher les g\u00e8nes qui causent le plus de vieillissement cellulaire. Ils ont identifi\u00e9 100 g\u00e8nes sur environ 10 000. Le g\u00e8ne kat7, a d\u00e9clar\u00e9 Qu, \u00e9tait le plus impliqu\u00e9 dans le vieillissement des cellules. C\u2019est l\u2019un des dizaines de milliers de g\u00e8nes trouv\u00e9s dans les cellules de mammif\u00e8res.

    Les chercheurs ont d\u00e9sactiv\u00e9 le g\u00e8ne kat7 dans le foie des souris de l\u2019\u00e9tude. Ils ont utilis\u00e9 une m\u00e9thode appel\u00e9e vecteur lentiviral pour modifier le g\u00e8ne en ins\u00e9rant un mat\u00e9riel g\u00e9n\u00e9tique dans la cellule. Leurs r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans le journal Science Translational Medicine au d\u00e9but de janvier. Qu a d\u00e9clar\u00e9 avoir test\u00e9 le fonctionnement du g\u00e8ne kat7 dans diff\u00e9rents types de cellules, y compris les cellules souches humaines, les cellules h\u00e9patiques humaines et les cellules h\u00e9patiques de souris. Pour toutes ces cellules, les chercheurs n\u2019ont trouv\u00e9 aucune toxicit\u00e9 cellulaire. \u201cEt pour les souris, a-t-elle ajout\u00e9,\u201d nous n\u2019avons pas non plus encore vu d\u2019effets secondaires.

    M\u00eame avec ces r\u00e9sultats, a d\u00e9clar\u00e9 Qu \u00e0 Reuters, la m\u00e9thode pour d\u00e9sactiver le g\u00e8ne kat7 est encore loin d\u2019\u00eatre pr\u00eate pour les tests humains. Elle a dit qu\u2019ils avaient besoin de plus de tests dans d\u2019autres cellules humaines et organes de souris avant d\u2019exp\u00e9rimenter la m\u00e9thode sur le vieillissement humain et d\u2019autres conditions de sant\u00e9. Qu a d\u00e9clar\u00e9 qu\u2019elle esp\u00e9rait pouvoir tester la m\u00e9thode sur les primates ensuite. Mais cela exigerait d\u2019abord beaucoup d\u2019argent et beaucoup plus de recherches. \u201cEn fin de compte\u201d, a-t-elle d\u00e9clar\u00e9, \u201cnous esp\u00e9rons pouvoir trouver un moyen de retarder le vieillissement, m\u00eame d\u2019un tr\u00e8s petit pourcentage \u2026 \u00e0 l\u2019avenir.\u201d<\/p><\/div><\/div>\n<\/div><\/div>\n\n\n\n

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    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